Assay Detail
Binding
CHEMBL649240
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Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central alpha 2-antagonistic activity as potential antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.49 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162682 | — | — | 1 | 9.21 |
| CHEMBL165350 | — | — | 1 | 9.16 |
| CHEMBL162490 | — | — | 1 | 9.15 |
| CHEMBL351483 | — | — | 1 | 9.14 |
| CHEMBL162232 | — | — | 1 | 9.07 |
| CHEMBL163190 | — | — | 1 | 8.97 |
| CHEMBL165796 | — | — | 1 | 8.92 |
| CHEMBL162370 | — | — | 1 | 8.89 |
| CHEMBL351200 | — | — | 1 | 8.88 |
| CHEMBL163247 | — | — | 1 | 8.87 |
| CHEMBL162826 | — | — | 1 | 8.79 |
| CHEMBL162501 | LUSAPERIDONE | 2.0 | 1 | 8.77 |
| CHEMBL164612 | — | — | 1 | 8.65 |
| CHEMBL162436 | — | — | 1 | 8.57 |
| CHEMBL162147 | — | — | 1 | 8.44 |
| CHEMBL165776 | — | — | 1 | 8.18 |
| CHEMBL165181 | — | — | 1 | 7.85 |
| CHEMBL165677 | — | — | 1 | 7.56 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.27 |
| CHEMBL162058 | — | — | 1 | 7.24 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162682 | — | IC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL165350 | — | IC50 | = | 0.6918 | nM | 9.16 |
| CHEMBL162490 | — | IC50 | = | 0.7079 | nM | 9.15 |
| CHEMBL351483 | — | IC50 | = | 0.7244 | nM | 9.14 |
| CHEMBL162232 | — | IC50 | = | 0.8511 | nM | 9.07 |
| CHEMBL163190 | — | IC50 | = | 1.072 | nM | 8.97 |
| CHEMBL165796 | — | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL162370 | — | IC50 | = | 1.288 | nM | 8.89 |
| CHEMBL351200 | — | IC50 | = | 1.318 | nM | 8.88 |
| CHEMBL163247 | — | IC50 | = | 1.349 | nM | 8.87 |
| CHEMBL162826 | — | IC50 | = | 1.622 | nM | 8.79 |
| CHEMBL162501 | LUSAPERIDONE | IC50 | = | 1.698 | nM | 8.77 |
| CHEMBL164612 | — | IC50 | = | 2.239 | nM | 8.65 |
| CHEMBL162436 | — | IC50 | = | 2.692 | nM | 8.57 |
| CHEMBL162147 | — | IC50 | = | 3.631 | nM | 8.44 |
| CHEMBL165776 | — | IC50 | = | 6.607 | nM | 8.18 |
| CHEMBL165181 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL165677 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL10316 | IDAZOXAN | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL162058 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL654 | MIRTAZAPINE | IC50 | = | 199.53 | nM | 6.70 |