Assay Detail
Functional
CHEMBL643949
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Alpha-2 Adrenoceptor blocking activity as antagonism of clonidine-induced depression of field-stimulated prostatic rat vas deferens
14
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationships in prazosin-related compounds. 2. Role of the piperazine ring on alpha-blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 5.56 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27013 | — | — | 1 | 6.84 |
| CHEMBL159440 | — | — | 2 | 6.41 |
| CHEMBL159922 | — | — | 2 | 5.96 |
| CHEMBL160908 | — | — | 1 | 5.94 |
| CHEMBL162538 | — | — | 2 | 5.91 |
| CHEMBL606671 | — | — | 2 | 5.54 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.43 |
| CHEMBL159888 | — | — | 1 | 5.28 |
| CHEMBL351897 | — | — | 2 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27013 | — | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL159440 | — | Kd | = | 389.05 | nM | 6.41 |
| CHEMBL159922 | — | Kd | = | 1096.48 | nM | 5.96 |
| CHEMBL160908 | — | Kd | = | 1148.15 | nM | 5.94 |
| CHEMBL162538 | — | Kd | = | 1230.27 | nM | 5.91 |
| CHEMBL606671 | — | Kd | = | 2884.03 | nM | 5.54 |
| CHEMBL2 | PRAZOSIN | Kd | = | 3715.35 | nM | 5.43 |
| CHEMBL606671 | — | Kd | = | 3890.45 | nM | 5.41 |
| CHEMBL159888 | — | Kd | = | 5248.07 | nM | 5.28 |
| CHEMBL351897 | — | Kd | = | 7079.46 | nM | 5.15 |
| CHEMBL351897 | — | Kd | = | 8317.64 | nM | 5.08 |
| CHEMBL162538 | — | Kd | = | 8912.51 | nM | 5.05 |
| CHEMBL159922 | — | Kd | = | 9120.11 | nM | 5.04 |
| CHEMBL159440 | — | Kd | = | 13803.84 | nM | 4.86 |