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Compound Detail

CHEMBL159922

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COc1cc2nc(NC3CCCCC3NC(=O)c3ccco3)nc(N)c2cc1OC

Basic Information

ChEMBL ID CHEMBL159922
Phase Preclinical
Structure Type MOL
InChI Key MSGBLZQFUURDGG-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

411.5
MW (Da)
2.98
ALogP
8
HBA
3
HBD
124.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25N5O4
MW 411.46
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -0.89

Activity Summary

Kd 4 meas. best 6.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 6.07 5.905 851.1 2
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 5.96 5.5 1096.5 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8096245 10.1021/jm00058a005 Adrenergic receptor alpha-1 2
8096245 10.1021/jm00058a005 Adrenergic receptor alpha-2 2
8096245 10.1021/jm00058a005 Unchecked 2

Data from ChEMBL 36 via Core Engine