Assay Detail
Functional
CHEMBL644686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Alpha-1 Adrenoceptor blocking activity as antagonism of norepinephrine-induced contractions of epididymal portion of rat vas deferens
14
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationships in prazosin-related compounds. 2. Role of the piperazine ring on alpha-blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 7.54 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351897 | — | — | 2 | 8.97 |
| CHEMBL27013 | — | — | 1 | 8.93 |
| CHEMBL159440 | — | — | 2 | 8.75 |
| CHEMBL159888 | — | — | 1 | 8.61 |
| CHEMBL162538 | — | — | 2 | 8.55 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.54 |
| CHEMBL160908 | — | — | 1 | 8.13 |
| CHEMBL159922 | — | — | 2 | 6.07 |
| CHEMBL606671 | — | — | 2 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351897 | — | Kd | = | 1.072 | nM | 8.97 |
| CHEMBL27013 | — | Kd | = | 1.175 | nM | 8.93 |
| CHEMBL159440 | — | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL159888 | — | Kd | = | 2.455 | nM | 8.61 |
| CHEMBL162538 | — | Kd | = | 2.818 | nM | 8.55 |
| CHEMBL2 | PRAZOSIN | Kd | = | 2.884 | nM | 8.54 |
| CHEMBL160908 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL351897 | — | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL159440 | — | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL162538 | — | Kd | = | 81.28 | nM | 7.09 |
| CHEMBL159922 | — | Kd | = | 851.14 | nM | 6.07 |
| CHEMBL606671 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL159922 | — | Kd | = | 1819.7 | nM | 5.74 |
| CHEMBL606671 | — | Kd | = | 2290.87 | nM | 5.64 |