Compound Detail
CHEMBL159440
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Basic Information
| ChEMBL ID | CHEMBL159440 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIFKQOWGMIEMLH-ZGTCLIOFSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
411.5
MW (Da)
2.56
ALogP
8
HBA
1
HBD
107.0
PSA (Ų)
0.70
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 8.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-1 CHEMBL1907610 | Kd | 8.75 | 7.935 | 1.8 | 2 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | Kd | 6.41 | 5.635 | 389.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-1 | Kd | = | 1.778 | nM | 8.75 | Alpha-1 Adrenoceptor blocking activity as antagonism of norepinephrine-induced c... | 8096245 |
| Adrenergic receptor alpha-1 | Kd | = | 75.86 | nM | 7.12 | Alpha-1 Adrenoceptor blocking activity as antagonism of norepinephrine-induced c... | 8096245 |
| Adrenergic receptor alpha-2 | Kd | = | 389.05 | nM | 6.41 | Alpha-2 Adrenoceptor blocking activity as antagonism of clonidine-induced depres... | 8096245 |
| Adrenergic receptor alpha-2 | Kd | = | 13803.84 | nM | 4.86 | Alpha-2 Adrenoceptor blocking activity as antagonism of clonidine-induced depres... | 8096245 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8096245 | 10.1021/jm00058a005 | Adrenergic receptor alpha-1 | 2 |
| 8096245 | 10.1021/jm00058a005 | Adrenergic receptor alpha-2 | 2 |
| 8096245 | 10.1021/jm00058a005 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine