Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL162538

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CCC1[C@@H](CC)N(c2nc(N)c3cc(OC)c(OC)cc3n2)CCN1C(=O)c1ccco1

Basic Information

ChEMBL ID CHEMBL162538
Phase Preclinical
Structure Type MOL
InChI Key XUILCHHAFRZYQV-ZYMOGRSISA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

439.5
MW (Da)
3.34
ALogP
8
HBA
1
HBD
107.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H29N5O4
MW 439.52
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.76

Activity Summary

Kd 4 meas. best 8.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 8.55 7.82 2.8 2
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 5.91 5.48 1230.3 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8096245 10.1021/jm00058a005 Adrenergic receptor alpha-1 2
8096245 10.1021/jm00058a005 Adrenergic receptor alpha-2 2
8096245 10.1021/jm00058a005 Unchecked 2

Data from ChEMBL 36 via Core Engine