Assay Detail
Binding
CHEMBL672657
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Binding affinity for Dopamine receptor D2 using [3H]spiperone in rat brain
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.21 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72162 | — | — | 1 | 7.57 |
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 6.66 |
| CHEMBL355107 | — | — | 1 | 6.52 |
| CHEMBL91310 | — | — | 1 | 6.52 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.56 |
| CHEMBL88870 | — | — | 1 | 5.32 |
| CHEMBL328246 | — | — | 1 | 5.30 |
| CHEMBL73082 | — | — | 1 | - |
| CHEMBL73538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72162 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL415300 | ISOCLOZAPINE | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL355107 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL91310 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL88870 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL328246 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL73082 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL73538 | — | IC50 | > | 10000.0 | nM | - |