Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL355107

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21

Basic Information

ChEMBL ID CHEMBL355107
Phase Preclinical
Structure Type MOL
InChI Key PRRVUGWDILXJOU-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

336.9
MW (Da)
4.46
ALogP
2
HBA
0
HBD
6.5
PSA (Ų)
0.76
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21ClN2
MW 336.87
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -0.10

Activity Summary

IC50 3 meas. best 7.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(1A) dopamine receptor
CHEMBL265
IC50 7.29 7.29 51.0 1
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 6.61 6.61 248.0 1
D(2) dopamine receptor
CHEMBL339
IC50 6.52 6.52 300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1967652 10.1021/jm00164a053 Muscarinic acetylcholine receptor 1
1967652 10.1021/jm00164a053 D(1A) dopamine receptor 1
1967652 10.1021/jm00164a053 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine