Assay Detail
Binding
CHEMBL673628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrrole mannich bases as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 8.03 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.70 |
| CHEMBL152311 | — | — | 1 | 9.35 |
| CHEMBL346168 | — | — | 1 | 9.19 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 9.10 |
| CHEMBL153136 | — | — | 1 | 8.96 |
| CHEMBL155506 | — | — | 1 | 8.85 |
| CHEMBL434512 | — | — | 1 | 8.80 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 8.66 |
| CHEMBL152458 | — | — | 1 | 8.64 |
| CHEMBL348002 | — | — | 1 | 8.51 |
| CHEMBL347782 | — | — | 1 | 8.48 |
| CHEMBL345506 | — | — | 1 | 8.48 |
| CHEMBL357286 | — | — | 1 | 8.34 |
| CHEMBL347056 | — | — | 1 | 8.30 |
| CHEMBL347334 | — | — | 1 | 8.17 |
| CHEMBL152363 | — | — | 1 | 8.15 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.11 |
| CHEMBL348241 | — | — | 1 | 8.03 |
| CHEMBL152776 | — | — | 1 | 8.02 |
| CHEMBL348014 | — | — | 1 | 7.89 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 7.69 |
| CHEMBL153335 | — | — | 1 | 7.65 |
| CHEMBL153451 | — | — | 1 | 7.45 |
| CHEMBL152336 | — | — | 1 | 7.27 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.27 |
| CHEMBL153490 | — | — | 1 | 7.26 |
| CHEMBL153219 | — | — | 1 | 7.18 |
| CHEMBL152424 | — | — | 1 | 7.10 |
| CHEMBL357532 | — | — | 1 | 7.00 |
| CHEMBL151966 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL152311 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL346168 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL153136 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL155506 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL434512 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL422 | TRIFLUOPERAZINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL152458 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL348002 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL345506 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL347782 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL357286 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL347056 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL347334 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL152363 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL348241 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL152776 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL348014 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 20.6 | nM | 7.69 |
| CHEMBL153335 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL153451 | — | Ki | = | 35.2 | nM | 7.45 |
| CHEMBL152336 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL42 | CLOZAPINE | Ki | = | 53.6 | nM | 7.27 |
| CHEMBL153490 | — | Ki | = | 54.9 | nM | 7.26 |
| CHEMBL153219 | — | Ki | = | 65.5 | nM | 7.18 |
| CHEMBL152424 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL357532 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL151966 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL49 | BUSPIRONE | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL152204 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL152617 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL153161 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL9666 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL346881 | — | Ki | > | 100.0 | nM | - |
| CHEMBL153263 | — | Ki | > | 100.0 | nM | - |
| CHEMBL152867 | — | Ki | > | 80.0 | nM | - |
| CHEMBL346459 | — | Ki | > | 1000.0 | nM | - |