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Assay Detail

CHEMBL673680

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against lipid peroxidation of egg-phosphatidylcholine (PC) liposome caused by water-soluble radical initiator [2,2'-azobis(2-amidinopropane) dihydrochloride] (AAPH)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and antioxidant activity of novel amphipathic derivatives of tea polyphenol.
Tanaka T, Kusano R, Kouno I.
Bioorg Med Chem Lett (1998) 8 : 1801 -1806
PubMed 9873437 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.83 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL299731 1 5.10
CHEMBL297716 1 5.06
CHEMBL50515 1 5.02
CHEMBL2303843 1 5.00
CHEMBL52271 1 4.94
CHEMBL52214 1 4.92
CHEMBL277346 OCTYL_GALLATE 1 4.73
CHEMBL51024 1 4.69
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 4.68
CHEMBL52561 1 4.61
CHEMBL47 ALPHA-TOCOPHEROL 1 4.39
CHEMBL51442 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL299731 IC50 = 7900.0 nM 5.10
CHEMBL297716 IC50 = 8800.0 nM 5.06
CHEMBL50515 IC50 = 9600.0 nM 5.02
CHEMBL2303843 IC50 = 10000.0 nM 5.00
CHEMBL52271 IC50 = 11600.0 nM 4.94
CHEMBL52214 IC50 = 12000.0 nM 4.92
CHEMBL277346 OCTYL_GALLATE IC50 = 18600.0 nM 4.73
CHEMBL51024 IC50 = 20500.0 nM 4.69
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 20800.0 nM 4.68
CHEMBL52561 IC50 = 24600.0 nM 4.61
CHEMBL47 ALPHA-TOCOPHEROL IC50 = 40300.0 nM 4.39
CHEMBL51442 IC50 = 135100.0 nM -