Assay Detail
Binding
CHEMBL676295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity to cloned rat Dopamine receptor D3 measured by displacement of the radioligand [3H]sulpiride
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.33 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28651 | — | — | 1 | 7.34 |
| CHEMBL435949 | — | — | 1 | 6.17 |
| CHEMBL28833 | — | — | 1 | 6.04 |
| CHEMBL282829 | — | — | 1 | 5.77 |
| CHEMBL28997 | — | — | 1 | - |
| CHEMBL282424 | — | — | 1 | - |
| CHEMBL28607 | — | — | 1 | - |
| CHEMBL29808 | — | — | 1 | - |
| CHEMBL287671 | — | — | 1 | - |
| CHEMBL283036 | — | — | 1 | - |
| CHEMBL267014 | L-745870 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28651 | — | Ki | = | 45.7 | nM | 7.34 |
| CHEMBL435949 | — | Ki | = | 668.0 | nM | 6.17 |
| CHEMBL28833 | — | Ki | = | 921.0 | nM | 6.04 |
| CHEMBL282829 | — | Ki | = | 1692.0 | nM | 5.77 |
| CHEMBL28997 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL282424 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL28607 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL29808 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL287671 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL283036 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL267014 | L-745870 | Ki | > | 10000.0 | nM | - |