Assay Detail
Binding
CHEMBL677206
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Inhibition of epidermal growth factor receptor (EGFr)
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.34 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336409 | — | — | 2 | 6.05 |
| CHEMBL334915 | — | — | 1 | 5.46 |
| CHEMBL135577 | — | — | 1 | 5.34 |
| CHEMBL263666 | — | — | 1 | 5.33 |
| CHEMBL137422 | — | — | 1 | 5.21 |
| CHEMBL342929 | — | — | 1 | 5.16 |
| CHEMBL334439 | — | — | 1 | 5.16 |
| CHEMBL336410 | — | — | 1 | 5.16 |
| CHEMBL336174 | — | — | 1 | 5.13 |
| CHEMBL135861 | — | — | 1 | 4.89 |
| CHEMBL334973 | — | — | 1 | - |
| CHEMBL135241 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336409 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL336409 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL334915 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL135577 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL263666 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL137422 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL342929 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL334439 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL336410 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL336174 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL135861 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL334973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL135241 | — | IC50 | > | 50000.0 | nM | - |