Compound Detail
CHEMBL334915
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Basic Information
| ChEMBL ID | CHEMBL334915 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HNEORRPIDMAPCB-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
506.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.62 | 5.62 | 2400.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| NIH3T3 CHEMBL614822 | IC50 | 5.1 | 5.1 | 8000.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 4.76 | 4.76 | 17400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 2400.0 | nM | 5.62 | Inhibition of Src tyrosine kinase | 9046331 |
| Epidermal growth factor receptor | IC50 | = | 3500.0 | nM | 5.46 | Inhibition of epidermal growth factor receptor (EGFr) | 9046331 |
| NIH3T3 | IC50 | = | 8000.0 | nM | 5.1 | Inhibition of mouse Swiss 3T3 fibroblasts proliferation | 9046331 |
| Platelet-derived growth factor receptor beta | IC50 | = | 17400.0 | nM | 4.76 | Inhibition of Platelet-derived growth factor receptor beta (PDGFr) | 9046331 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9046331 | 10.1021/jm960689b | Epidermal growth factor receptor | 1 |
| 9046331 | 10.1021/jm960689b | Platelet-derived growth factor receptor beta | 1 |
| 9046331 | 10.1021/jm960689b | Unchecked | 1 |
| 9046331 | 10.1021/jm960689b | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine