Assay Detail
Binding
CHEMBL764162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor beta (PDGFr)
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.94 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263666 | — | — | 1 | 5.47 |
| CHEMBL137422 | — | — | 1 | 5.33 |
| CHEMBL135861 | — | — | 1 | 5.10 |
| CHEMBL135577 | — | — | 1 | 4.89 |
| CHEMBL336409 | — | — | 2 | 4.85 |
| CHEMBL334915 | — | — | 1 | 4.76 |
| CHEMBL342929 | — | — | 1 | 4.55 |
| CHEMBL334973 | — | — | 1 | - |
| CHEMBL135241 | — | — | 1 | - |
| CHEMBL336410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263666 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL137422 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL135861 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL135577 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL336409 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL334915 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL336409 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL342929 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL334973 | — | IC50 | > | 31000.0 | nM | - |
| CHEMBL135241 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL336410 | — | IC50 | > | 50000.0 | nM | - |