Assay Detail
Binding
CHEMBL678911
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Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; alpha-1/beta-2/gamma-2 (CHEMBL2095172) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 4.91 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29790 | — | — | 1 | 6.30 |
| CHEMBL526 | PROPOFOL | 4.0 | 1 | 5.70 |
| CHEMBL109956 | — | — | 1 | 5.60 |
| CHEMBL53267 | — | — | 1 | 5.00 |
| CHEMBL30014 | — | — | 1 | 4.90 |
| CHEMBL111084 | — | — | 1 | 4.80 |
| CHEMBL111762 | — | — | 1 | 4.70 |
| CHEMBL111198 | — | — | 1 | 4.60 |
| CHEMBL109774 | — | — | 1 | 4.50 |
| CHEMBL111740 | — | — | 1 | 4.40 |
| CHEMBL30018 | — | — | 1 | 4.40 |
| CHEMBL321841 | — | — | 1 | 4.00 |
| CHEMBL112891 | — | — | 1 | - |
| CHEMBL54049 | — | — | 1 | - |
| CHEMBL14060 | PHENOL | 4.0 | 1 | - |
| CHEMBL111140 | — | — | 1 | - |
| CHEMBL29873 | — | — | 1 | - |
| CHEMBL111766 | — | — | 1 | - |
| CHEMBL109652 | SYRINGOL | — | 1 | - |
| CHEMBL109663 | — | — | 1 | - |
| CHEMBL321211 | — | — | 1 | - |
| CHEMBL109470 | — | — | 1 | - |
| CHEMBL281071 | — | — | 1 | - |
| CHEMBL31352 | — | — | 1 | - |
| CHEMBL30106 | — | — | 1 | - |
| CHEMBL111507 | — | — | 1 | - |
| CHEMBL111194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29790 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL526 | PROPOFOL | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL109956 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL53267 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL30014 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL111084 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL111762 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL111198 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL109774 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL111740 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL30018 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL321841 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL112891 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL54049 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL14060 | PHENOL | EC50 | = | 1000000.0 | nM | - |
| CHEMBL111140 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL29873 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111766 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL109652 | SYRINGOL | EC50 | = | 100000000.0 | nM | - |
| CHEMBL109663 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL321211 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL109470 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL281071 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL31352 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL30106 | — | EC50 | = | 125892.54 | nM | - |
| CHEMBL111507 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111194 | — | EC50 | = | 100000000.0 | nM | - |