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Assay Detail

CHEMBL772774

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro contraction of rabbit aorta strips.
20
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Aorta
Confidence 1 — Organism
Curated By Expert

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators.
Rovnyak GC, Kimball SD, Beyer B, Cucinotta G, DiMarco JD, Gougoutas J, Hedberg A, Malley M, McCarthy JP, Zhang R.
J Med Chem (1995) 38 : 119 -129
PubMed 7837222 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.90 7.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283013 1 7.34
CHEMBL282706 3 6.23
CHEMBL25763 1 5.54
CHEMBL284266 1 5.45
CHEMBL23642 1 4.76
CHEMBL24491 1 -
CHEMBL279029 1 -
CHEMBL22704 3 -
CHEMBL23451 1 -
CHEMBL23720 1 -
CHEMBL280926 1 -
CHEMBL23386 1 -
CHEMBL23692 1 -
CHEMBL22705 1 -
CHEMBL193 NIFEDIPINE 4.0 1 -
CHEMBL282279 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283013 EC50 = 46.0 nM 7.34
CHEMBL282706 EC50 = 590.0 nM 6.23
CHEMBL282706 EC50 = 820.0 nM 6.09
CHEMBL25763 EC50 = 2900.0 nM 5.54
CHEMBL284266 EC50 = 3550.0 nM 5.45
CHEMBL23642 EC50 = 17300.0 nM 4.76
CHEMBL279029 EC50 > 30000.0 nM -
CHEMBL22704 EC50 > 30000.0 nM -
CHEMBL23451 EC50 > 30000.0 nM -
CHEMBL23720 EC50 > 30000.0 nM -
CHEMBL280926 EC50 > 30000.0 nM -
CHEMBL23386 EC50 > 30000.0 nM -
CHEMBL282706 EC50 > 30000.0 nM -
CHEMBL23692 EC50 > 30000.0 nM -
CHEMBL22705 EC50 > 30000.0 nM -
CHEMBL193 NIFEDIPINE EC50 > 30000.0 nM -
CHEMBL22704 EC50 > 30000.0 nM -
CHEMBL282279 EC50 > 30000.0 nM -
CHEMBL24491 EC50 > 30000.0 nM -
CHEMBL22704 EC50 > 30000.0 nM -