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Assay Detail

CHEMBL818953

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for the inhibition of VZV strains of OKA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Confidence 1 — Organism
Curated By Intermediate

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.
McGuigan C, Yarnold CJ, Jones G, Velázquez S, Barucki H, Brancale A, Andrei G, Snoeck R, De Clercq E, Balzarini J.
J Med Chem (1999) 42 : 4479 -4484
PubMed 10579812 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 6.81 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31634 BRIVUDINE 2.0 1 8.52
CHEMBL147871 1 8.10
CHEMBL144817 1 7.82
CHEMBL146310 1 7.70
CHEMBL3143033 1 6.77
CHEMBL3143162 1 6.30
CHEMBL3143164 1 5.89
CHEMBL3143032 1 5.89
CHEMBL184 ACYCLOVIR 4.0 1 5.54
CHEMBL3143047 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31634 BRIVUDINE EC50 = 3.0 nM 8.52
CHEMBL147871 EC50 = 8.0 nM 8.10
CHEMBL144817 EC50 = 15.0 nM 7.82
CHEMBL146310 EC50 = 20.0 nM 7.70
CHEMBL3143033 EC50 = 170.0 nM 6.77
CHEMBL3143162 EC50 = 500.0 nM 6.30
CHEMBL3143164 EC50 = 1300.0 nM 5.89
CHEMBL3143032 EC50 = 1300.0 nM 5.89
CHEMBL184 ACYCLOVIR EC50 = 2900.0 nM 5.54
CHEMBL3143047 EC50 = 3000.0 nM 5.52