Assay Detail
Functional
CHEMBL861935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency at muscarinic receptor M1 in rabbit vas deferens
16
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pKb | 7 | - | - |
| Intrinsic activity | 7 | - | - |
| EC50 | 2 | 4.75 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380572 | — | — | 3 | 5.05 |
| CHEMBL199636 | — | — | 3 | 4.44 |
| CHEMBL382846 | — | — | 2 | - |
| CHEMBL381913 | — | — | 2 | - |
| CHEMBL201016 | — | — | 2 | - |
| CHEMBL197604 | — | — | 2 | - |
| CHEMBL382659 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380572 | — | EC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL199636 | — | EC50 | = | 36307.81 | nM | 4.44 |
| CHEMBL380572 | — | pKb | - | — | - | |
| CHEMBL382846 | — | pKb | = | 5.6 | — | - |
| CHEMBL381913 | — | pKb | = | 6.77 | — | - |
| CHEMBL201016 | — | pKb | = | 5.75 | — | - |
| CHEMBL199636 | — | pKb | - | — | - | |
| CHEMBL197604 | — | pKb | = | 5.33 | — | - |
| CHEMBL382846 | — | Intrinsic activity | = | - | — | - |
| CHEMBL381913 | — | Intrinsic activity | = | 0.28 | — | - |
| CHEMBL201016 | — | Intrinsic activity | = | - | — | - |
| CHEMBL197604 | — | Intrinsic activity | = | - | — | - |
| CHEMBL199636 | — | Intrinsic activity | = | 0.94 | — | - |
| CHEMBL380572 | — | Intrinsic activity | = | 0.99 | — | - |
| CHEMBL382659 | — | pKb | = | 6.2 | — | - |
| CHEMBL382659 | — | Intrinsic activity | = | - | — | - |