Assay Detail
Functional
CHEMBL869197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.45 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.66 |
| CHEMBL424711 | — | — | 1 | 5.70 |
| CHEMBL373412 | — | — | 1 | 5.70 |
| CHEMBL215484 | — | — | 1 | 5.70 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 5.35 |
| CHEMBL212783 | — | — | 1 | 5.30 |
| CHEMBL215692 | — | — | 1 | 5.30 |
| CHEMBL379577 | — | — | 1 | 4.82 |
| CHEMBL211920 | — | — | 1 | 4.80 |
| CHEMBL213259 | — | — | 1 | 4.33 |
| CHEMBL377818 | — | — | 1 | 4.32 |
| CHEMBL215830 | — | — | 1 | - |
| CHEMBL212556 | — | — | 1 | - |
| CHEMBL215698 | — | — | 1 | - |
| CHEMBL215714 | — | — | 1 | - |
| CHEMBL211927 | — | — | 1 | - |
| CHEMBL378834 | — | — | 1 | - |
| CHEMBL214493 | — | — | 1 | - |
| CHEMBL211981 | — | — | 1 | - |
| CHEMBL213047 | — | — | 1 | - |
| CHEMBL380213 | — | — | 1 | - |
| CHEMBL212805 | — | — | 1 | - |
| CHEMBL213573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL424711 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL373412 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL215484 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL212783 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL215692 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL379577 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL211920 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL213259 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL377818 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL215830 | — | IC50 | = | 22800000.0 | nM | - |
| CHEMBL212556 | — | IC50 | = | 13800000.0 | nM | - |
| CHEMBL215698 | — | IC50 | > | 201000000.0 | nM | - |
| CHEMBL215714 | — | IC50 | = | 51500000.0 | nM | - |
| CHEMBL211927 | — | IC50 | = | 29900000.0 | nM | - |
| CHEMBL378834 | — | IC50 | = | 36900000.0 | nM | - |
| CHEMBL214493 | — | IC50 | = | 9300000.0 | nM | - |
| CHEMBL211981 | — | IC50 | = | 49000000.0 | nM | - |
| CHEMBL213047 | — | IC50 | = | 82900000.0 | nM | - |
| CHEMBL380213 | — | IC50 | = | 67000000.0 | nM | - |
| CHEMBL212805 | — | IC50 | = | 24000000.0 | nM | - |
| CHEMBL213573 | — | IC50 | = | 34700000.0 | nM | - |