Assay Detail
Binding
CHEMBL872888
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In vitro binding affinity for dopamine receptor D2 on rat striatal membranes by [3H]spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.96 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313095 | — | — | 1 | 8.07 |
| CHEMBL86662 | — | — | 1 | 8.06 |
| CHEMBL431367 | ROXINDOLE | 2.0 | 1 | 7.85 |
| CHEMBL87003 | — | — | 1 | 7.55 |
| CHEMBL554027 | — | — | 1 | 7.54 |
| CHEMBL423499 | — | — | 1 | 7.30 |
| CHEMBL314987 | — | — | 1 | 7.08 |
| CHEMBL87504 | — | — | 1 | 7.07 |
| CHEMBL85018 | — | — | 1 | 6.96 |
| CHEMBL84851 | — | — | 1 | 6.91 |
| CHEMBL314888 | — | — | 1 | 6.91 |
| CHEMBL86801 | — | — | 1 | 6.86 |
| CHEMBL87924 | — | — | 1 | 6.79 |
| CHEMBL87481 | — | — | 1 | 6.57 |
| CHEMBL418937 | — | — | 1 | 6.38 |
| CHEMBL86517 | — | — | 1 | 6.34 |
| CHEMBL86887 | — | — | 1 | 6.20 |
| CHEMBL315655 | — | — | 1 | 6.19 |
| CHEMBL90673 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313095 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL86662 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL431367 | ROXINDOLE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL87003 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL554027 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL423499 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL314987 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL87504 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL85018 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL84851 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL314888 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL86801 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL87924 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL87481 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL418937 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL86517 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL86887 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL315655 | — | Ki | = | 645.0 | nM | 6.19 |
| CHEMBL90673 | — | Ki | = | 2596.0 | nM | 5.59 |