Assay Detail
Functional
CHEMBL880174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against ligand-dependent EGF cell proliferation
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.57 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147112 | — | — | 1 | 4.72 |
| CHEMBL149201 | — | — | 1 | 4.66 |
| CHEMBL347074 | — | — | 1 | 4.66 |
| CHEMBL148984 | — | — | 1 | 4.64 |
| CHEMBL358728 | — | — | 1 | 4.62 |
| CHEMBL147761 | — | — | 1 | 4.54 |
| CHEMBL148514 | — | — | 1 | 4.52 |
| CHEMBL146694 | — | — | 1 | 4.50 |
| CHEMBL450622 | — | — | 1 | 4.31 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
| CHEMBL443296 | — | — | 1 | - |
| CHEMBL149243 | — | — | 1 | - |
| CHEMBL149073 | — | — | 1 | - |
| CHEMBL146697 | — | — | 1 | - |
| CHEMBL357803 | — | — | 1 | - |
| CHEMBL89363 | — | — | 1 | - |
| CHEMBL344319 | — | — | 1 | - |
| CHEMBL356245 | — | — | 1 | - |
| CHEMBL150151 | — | — | 1 | - |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | - |
| CHEMBL148744 | — | — | 1 | - |
| CHEMBL150177 | — | — | 1 | - |
| CHEMBL435227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147112 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL149201 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL347074 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL148984 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL358728 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL147761 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL148514 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL146694 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL450622 | — | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL276711 | SEMAXANIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL443296 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL149243 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL149073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL146697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL357803 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL89363 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL344319 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL356245 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL150151 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL274654 | ORANTINIB | IC50 | > | 50000.0 | nM | - |
| CHEMBL148744 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL150177 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL435227 | — | IC50 | > | 50000.0 | nM | - |