Assay Detail
Binding
CHEMBL992754
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Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5A, mitochondrial (CHEMBL4789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.22 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.20 |
| CHEMBL24147 | RESORCINOL | -1.0 | 1 | 5.06 |
| CHEMBL441343 | PARABEN | — | 1 | 5.04 |
| CHEMBL261219 | — | — | 1 | 4.92 |
| CHEMBL537 | HYDROQUINONE | 4.0 | 1 | 4.85 |
| CHEMBL280998 | CATECHOL | — | 1 | 4.26 |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | - |
| CHEMBL66381 | 4-CYANOPHENOL | — | 1 | - |
| CHEMBL1142 | 4-AMINOPHENOL | — | 1 | - |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL24147 | RESORCINOL | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL441343 | PARABEN | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL261219 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL537 | HYDROQUINONE | Ki | = | 14100.0 | nM | 4.85 |
| CHEMBL280998 | CATECHOL | Ki | = | 55100.0 | nM | 4.26 |
| CHEMBL112 | ACETAMINOPHEN | Ki | = | 802000.0 | nM | - |
| CHEMBL66381 | 4-CYANOPHENOL | Ki | = | 520000.0 | nM | - |
| CHEMBL1142 | 4-AMINOPHENOL | Ki | = | 867000.0 | nM | - |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 678000.0 | nM | - |