Compound Detail
CHEMBL1079421
PHENMEDIPHAM Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1079421 |
| Name | PHENMEDIPHAM |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IDOWTHOLJBTAFI-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
300.3
MW (Da)
3.78
ALogP
4
HBA
2
HBD
76.7
PSA (Ų)
0.90
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 7.11 | 7.11 | 77.0 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 6.82 | 6.62 | 152.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 77.0 | nM | 7.11 | Inhibition of rat FAAH | 19850474 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 152.0 | nM | 6.82 | Inhibition of human FAAH-mediated hydrolysis of [3H]AEA | 19850474 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 377.0 | nM | 6.42 | Inhibition of human FAAH | 19850474 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19850474 | 10.1016/j.bmcl.2009.09.086 | Fatty-acid amide hydrolase 1 | 7 |
| 19850474 | 10.1016/j.bmcl.2009.09.086 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine