Compound Detail
CHEMBL1234
DEFEROXAMINE MESYLATE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN.CS(=O)(=O)O
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
17
Publications
9
Known Names
3
Indications
1
Mechanisms
Molecular Properties
560.7
MW (Da)
0.92
ALogP
9
HBA
6
HBD
205.8
PSA (Ų)
0.06
QED
2
Ro5 Violations
23
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1968 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Iron chelating agent | CHELATING AGENT | Iron | ✓ | ✓ |
Indications
Iron Overload Cerebral Hemorrhage Diabetes Mellitus, Type 1
Activity Summary
EC50 5 meas. best 6.24
IC50 1 meas. best 5.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.24 | 6.24 | 578.0 | 1 |
| ATP-dependent molecular chaperone HSP82 CHEMBL1293251 | EC50 | 6.14 | 6.14 | 727.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.34 | 5.34 | 4533.8 | 1 |
| No relevant target CHEMBL2362975 | EC50 | 4.7 | 4.7 | 20000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 578.0 | nM | 6.24 | PUBCHEM_BIOASSAY: Fluorescence Cell-Based Retest of Candida albicans Growth in t... | - |
| ATP-dependent molecular chaperone HSP82 | EC50 | = | 727.0 | nM | 6.14 | PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors... | - |
| Unchecked | IC50 | = | 4533.8 | nM | 5.34 | PubChem BioAssay. VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area de... | - |
| No relevant target | EC50 | = | 20000.0 | nM | 4.7 | Binding affinity to Fe3+ assessed as formation of Fe3+-compound complex incubate... | 32058711 |
| No relevant target | EC50 | = | 20200.0 | nM | 4.7 | Binding affinity to Fe3+ assessed as compound-Fe3+ complex formation incubated f... | 33983744 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35123296 | 10.1016/j.ejmech.2022.114151 | No relevant target | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 28840714 | 10.1021/acs.jnatprod.7b00328 | No relevant target | 1 |
| 33983744 | 10.1021/acs.jnatprod.1c00061 | No relevant target | 1 |
| 32058711 | 10.1021/acs.jnatprod.9b00698 | No relevant target | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| 14521410 | 10.1021/jm030191r | Beta-lactamase | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 20843939 | 10.1124/dmd.110.035113 | Hepatotoxicity | 1 |
| 20553011 | 10.1021/tx1000865 | Hepatotoxicity | 1 |
| 17319723 | 10.1021/np060502b | Unchecked | 1 |
| 14521410 | 10.1021/jm030191r | Malate dehydrogenase, cytoplasmic | 1 |
| 14521410 | 10.1021/jm030191r | Chymotrypsin-C | 1 |
Data from ChEMBL 36 via Core Engine