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Compound Detail

CHEMBL1372085

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O=Nc1c2[nH]c3ccccc3[n+]([O-])c-2c2ccccc12

Basic Information

ChEMBL ID CHEMBL1372085
Phase Preclinical
Structure Type MOL
InChI Key FGPNGERSNAXZQI-UHFFFAOYSA-N
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

263.3
MW (Da)
3.46
ALogP
3
HBA
1
HBD
72.2
PSA (Ų)
0.32
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H9N3O2
MW 263.26
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness 0.05

Activity Summary

EC50 3 meas. best 5.07
IC50 3 meas. best 5.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mitogen-activated protein kinase 10
CHEMBL2637
IC50 5.47 5.47 3356.0 1
Unchecked
CHEMBL612545
EC50 5.07 4.935 8474.0 2
Unchecked
CHEMBL612545
IC50 4.97 4.94 10730.0 2
H4
CHEMBL1075452
EC50 4.9 4.9 12479.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine