Compound Detail
CHEMBL1443660
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Basic Information
| ChEMBL ID | CHEMBL1443660 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCFWDEDFGYEOSX-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
367.8
MW (Da)
2.04
ALogP
5
HBA
3
HBD
92.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 6.49
IC50 1 meas. best 4.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Streptokinase A CHEMBL1293228 | EC50 | 6.49 | 6.49 | 325.0 | 1 |
| Streptococcus sp. 'group A' CHEMBL612389 | EC50 | 6.24 | 6.24 | 571.0 | 1 |
| Streptococcus CHEMBL612313 | EC50 | 5.64 | 5.64 | 2294.0 | 1 |
| Large ribosomal subunit protein eL19A CHEMBL1741172 | EC50 | 4.96 | 4.96 | 10990.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.46 | 4.46 | 34908.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Streptokinase A | EC50 | = | 325.0 | nM | 6.49 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptococcus sp. 'group A' | EC50 | = | 571.0 | nM | 6.24 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptococcus | EC50 | = | 2294.0 | nM | 5.64 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... | - |
| Large ribosomal subunit protein eL19A | EC50 | = | 10990.0 | nM | 4.96 | PUBCHEM_BIOASSAY: Dose Response of TOR pathway GFP-fusion proteins in Saccharomy... | - |
| Unchecked | IC50 | = | 34908.0 | nM | 4.46 | PubChem BioAssay. QFRET-based biochemical high throughput dose response assay to... | - |
Data from ChEMBL 36 via Core Engine