Compound Detail
CHEMBL1446983
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Basic Information
| ChEMBL ID | CHEMBL1446983 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXBYIIARRIMNFJ-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
196.2
MW (Da)
2.94
ALogP
2
HBA
1
HBD
37.3
PSA (Ų)
0.70
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 5.21 | 5.21 | 6133.0 | 1 |
| Protein Rev CHEMBL1293282 | IC50 | 4.86 | 4.86 | 13868.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.48 | 4.47 | 33100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 6133.0 | nM | 5.21 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Protein Rev | IC50 | = | 13868.0 | nM | 4.86 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarizati... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 33100.0 | nM | 4.48 | PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 34520.0 | nM | 4.46 | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetyla... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19630386 | 10.1021/jf901052e | Pseudocercospora fijiensis | 1 |
Data from ChEMBL 36 via Core Engine