Compound Detail
CHEMBL1463422
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Basic Information
| ChEMBL ID | CHEMBL1463422 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCTCUPLYBJWMPU-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
330.8
MW (Da)
4.07
ALogP
7
HBA
1
HBD
81.0
PSA (Ų)
0.66
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 CHEMBL1741194 | IC50 | 5.64 | 5.36 | 2280.0 | 2 |
| Mitochondrial import inner membrane translocase subunit TIM23 CHEMBL1741180 | IC50 | 5.58 | 5.58 | 2660.0 | 1 |
| Calpain-2 catalytic subunit CHEMBL4143 | IC50 | 5.31 | 5.31 | 4907.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 2280.0 | nM | 5.64 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| Mitochondrial import inner membrane translocase subunit TIM23 | IC50 | = | 2660.0 | nM | 5.58 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| Calpain-2 catalytic subunit | IC50 | = | 4907.91 | nM | 5.31 | PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of a... | - |
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 8340.0 | nM | 5.08 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
Data from ChEMBL 36 via Core Engine