Compound Detail
CHEMBL1497773
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Basic Information
| ChEMBL ID | CHEMBL1497773 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RHSGOMCGIGMUBD-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
304.4
MW (Da)
4.78
ALogP
2
HBA
1
HBD
42.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.27
IC50 2 meas. best 5.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4H CHEMBL1293274 | IC50 | 5.94 | 5.94 | 1140.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 5.88 | 5.88 | 1320.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 5.27 | 5.27 | 5392.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 5.06 | 5.06 | 8651.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Eukaryotic translation initiation factor 4H | IC50 | = | 1140.0 | nM | 5.94 | PUBCHEM_BIOASSAY: SAR analysis for the identification of translation initiation ... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 1320.0 | nM | 5.88 | PUBCHEM_BIOASSAY: SAR analysis for the identification of translation initiation ... | - |
| Zinc finger protein mex-5 | EC50 | = | 5392.0 | nM | 5.27 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| RNA-binding protein pos-1 | EC50 | = | 8651.0 | nM | 5.06 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Data from ChEMBL 36 via Core Engine