Compound Detail
CHEMBL1567874
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Basic Information
| ChEMBL ID | CHEMBL1567874 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NRSRRFJWMFFOEC-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
341.4
MW (Da)
4.87
ALogP
3
HBA
0
HBD
39.1
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 5.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| H4 CHEMBL1075452 | EC50 | 5.15 | 5.15 | 7101.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 4.95 | 4.61 | 11360.0 | 2 |
| Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein CHEMBL3885546 | EC50 | 4.89 | 4.89 | 12900.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.46 | 4.46 | 34733.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.33 | 4.33 | 46630.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| H4 | EC50 | = | 7101.0 | nM | 5.15 | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activato... | - |
| Unchecked | EC50 | = | 11360.0 | nM | 4.95 | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activato... | - |
| Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | EC50 | = | 12900.0 | nM | 4.89 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule ago... | - |
| Zinc finger protein mex-5 | EC50 | = | 34733.0 | nM | 4.46 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| RNA-binding protein pos-1 | EC50 | = | 46630.0 | nM | 4.33 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Unchecked | EC50 | = | 54198.0 | nM | 4.27 | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Acti... | - |
Data from ChEMBL 36 via Core Engine