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Compound Detail

CHEMBL1572510

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CCOC(=O)c1sc(NC(=O)CNCc2ccccn2)c(C(=O)OCC)c1C

Basic Information

ChEMBL ID CHEMBL1572510
Phase Preclinical
Structure Type MOL
InChI Key HKJUYDIDBIUBLJ-UHFFFAOYSA-N
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

405.5
MW (Da)
2.53
ALogP
8
HBA
2
HBD
106.6
PSA (Ų)
0.62
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H23N3O5S
MW 405.48
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -2.08

Activity Summary

EC50 5 meas. best 6.71
IC50 1 meas. best 5.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Streptococcus sp. 'group A'
CHEMBL612389
EC50 6.71 6.71 195.0 1
Unchecked
CHEMBL612545
IC50 5.56 5.56 2769.0 1
Streptococcus
CHEMBL612313
EC50 5.3 5.3 5055.0 1
Unchecked
CHEMBL612545
EC50 5.05 4.9967 8921.0 3

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine