Compound Detail
CHEMBL1995565
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Basic Information
| ChEMBL ID | CHEMBL1995565 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WSFNRHXDVPZJBI-UFWORHAWSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
363.6
MW (Da)
5.35
ALogP
2
HBA
2
HBD
48.4
PSA (Ų)
0.59
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.34
IC50 2 meas. best 4.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein CHEMBL3885546 | EC50 | 6.34 | 6.34 | 460.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.31 | 5.31 | 4860.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.88 | 4.88 | 13069.0 | 1 |
| Insulin-degrading enzyme CHEMBL1293287 | IC50 | 4.42 | 4.42 | 38211.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein | EC50 | = | 460.0 | nM | 6.34 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule ago... | - |
| Unchecked | EC50 | = | 4860.0 | nM | 5.31 | PUBCHEM_BIOASSAY: HCS for Compounds that Up-Regulate Insulin Promoter Activity i... | - |
| Unchecked | IC50 | = | 13069.0 | nM | 4.88 | PUBCHEM_BIOASSAY: Counterscreen for IDE inhibitors: Luminescence-based cell-base... | - |
| Insulin-degrading enzyme | IC50 | = | 38211.0 | nM | 4.42 | PUBCHEM_BIOASSAY: Dose Response: Fluorescence polarization-based cell-based high... | - |
Data from ChEMBL 36 via Core Engine