Compound Detail
CHEMBL202969
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Basic Information
| ChEMBL ID | CHEMBL202969 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JBFFEVKDAYLOKF-UHFFFAOYSA-N |
3
Targets
4
Activities
3
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
259.3
MW (Da)
3.24
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.94
IC50 1 meas. best 6.45
Ki 1 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 7.82 | 7.82 | 15.0 | 1 |
| Plasmodium yoelii CHEMBL612889 | IC50 | 6.45 | 6.45 | 352.0 | 1 |
| Plasmodium falciparum CHEMBL364 | EC50 | 5.94 | 5.94 | 1138.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 15.0 | nM | 7.82 | Displacement of [3H]flumazenil from GABA-A receptor in rat cortical membranes | 16610795 |
| Plasmodium yoelii | IC50 | = | 352.0 | nM | 6.45 | NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium ... | 22096101 |
| Plasmodium falciparum | EC50 | = | 1138.0 | nM | 5.94 | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation ... | 18579783 |
| Plasmodium falciparum | EC50 | = | 1151.0 | nM | 5.94 | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferati... | 18579783 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22096101 | 10.1126/science.1211936 | Plasmodium yoelii | 3 |
| 18579783 | 10.1073/pnas.0802982105 | Plasmodium falciparum | 2 |
| 16610795 | 10.1021/jm058057p | GABA-A receptor; anion channel | 1 |
| 18579783 | 10.1073/pnas.0802982105 | Unchecked | 1 |
| 18579783 | 10.1073/pnas.0802982105 | Huh-7 | 1 |
Data from ChEMBL 36 via Core Engine