Compound Detail

CHEMBL2062335

METOPROLOL TARTRATE

💊 Approved Drug

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💊 Approved Drug

COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc1ccc(OCC(O)CNC(C)C)cc1.O=C(O)C(O)C(O)C(=O)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2062335
Name	METOPROLOL TARTRATE
Phase	Approved
Structure Type	MOL
InChI Key	YGULWPYYGQCFMP-UHFFFAOYSA-N
Therapeutic	✓ Yes
Parent Compound	CHEMBL13
Active Moiety	CHEMBL13

Known Names

Arbralene Beloc Beloc cor Betaloc Betaloc s.a. CGP-2175E Lopresor Lopresor sr Lopressor Mepranix 100 Mepranix 50 Metoprolol hemitartrate +10 more

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Mechanisms

Molecular Properties

267.4

MW (Da)

1.61

ALogP

HBA

HBD

50.7

PSA (Å²)

0.71

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
First Approval	1978
Availability	Prescription
Chirality	Racemic

Routes of Administration

Oral Parenteral

Flags

Black Box Warning

USAN Stem	-olol
USAN Year	1978

Extended Properties

Molecular Formula	C34H56N2O12
MW	684.82
Aromatic Rings	1
Heavy Atoms	19
NP-Likeness	-0.38

Mechanism of Action

Mechanism	Action Type	Target	Direct	Efficacy
Beta-1 adrenergic receptor antagonist	ANTAGONIST	Beta-1 adrenergic receptor	✓	✓

Indications

Angina Pectoris Heart Failure Hypertension Myocardial Infarction Stroke Atrial Fibrillation Heart Diseases

Drug Warnings

Black Box Warning

cardiotoxicity

Country: United States

Activity Summary

EC50 4 meas. best 5.52

IC50 2 meas. best 4.9

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
HEK293 CHEMBL614818	EC50	5.52	5.52	2994.0	1
Neuropeptide Y receptor type 1 CHEMBL4777	EC50	5.02	4.74	9606.0	2
Plasmodium falciparum CHEMBL364	IC50	4.9	4.85	12589.2	2
Neuropeptide Y receptor type 2 CHEMBL4018	EC50	4.79	4.79	16153.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
HEK293	EC50	=	2994.0	nM	5.52	PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists ...	-
Neuropeptide Y receptor type 1	EC50	=	9606.0	nM	5.02	PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-...	-
Plasmodium falciparum	IC50	=	12589.25	nM	4.9	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR gr...	19734910
Plasmodium falciparum	IC50	=	15848.93	nM	4.8	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR g...	19734910
Neuropeptide Y receptor type 2	EC50	=	16153.0	nM	4.79	PUBCHEM_BIOASSAY: Fluorescence-based cell-based high-throughput dose response as...	-
Neuropeptide Y receptor type 1	EC50	=	34827.0	nM	4.46	PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists ...	-

Literature References

PubMed	DOI	Target Context	# Activities
19734910	10.1038/nchembio.215	Plasmodium falciparum	2
-	10.6019/CHEMBL4495565	SARS-CoV-2	2
-	10.6019/CHEMBL4808148	Histone deacetylase 6	2
17417631	10.1038/nchembio873	Unchecked	1
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B1	1
23571415	10.1124/mol.112.084152	Solute carrier organic anion transporter family member 1B3	1
-	10.21203/rs.3.rs-23951/v1	SARS-CoV-2	1
-	10.6019/CHEMBL4495564	Replicase polyprotein 1ab	1

Data from ChEMBL 36 via Core Engine