Compound Detail
CHEMBL253348
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Basic Information
| ChEMBL ID | CHEMBL253348 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RURVWNUUUXCYRB-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
257.3
MW (Da)
2.18
ALogP
3
HBA
1
HBD
54.9
PSA (Ų)
0.88
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 CHEMBL4477 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.41 | 4.385 | 38700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | IC50 | = | 7000.0 | nM | 5.16 | Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed... | 18173231 |
| Polyadenylate-binding protein 1 | IC50 | = | 38700.0 | nM | 4.41 | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetyla... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 43300.0 | nM | 4.36 | PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18173231 | 10.1021/jm0611298 | Metabotropic glutamate receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine