Compound Detail
CHEMBL278255
CLINAFLOXACIN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL278255 |
| Name | CLINAFLOXACIN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | QGPKADBNRMWEQR-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
18
PK Parameters
20
Publications
3
Known Names
Molecular Properties
365.8
MW (Da)
2.36
ALogP
5
HBA
2
HBD
88.6
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
EC50 3 meas. best 7.19
IC50 2 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Streptokinase A CHEMBL1293228 | EC50 | 7.19 | 7.19 | 64.0 | 1 |
| Streptococcus sp. 'group A' CHEMBL612389 | EC50 | 6.94 | 6.94 | 115.0 | 1 |
| Streptococcus CHEMBL612313 | EC50 | 6.85 | 6.85 | 142.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 18000.0 | ng.hr.mL-1 | Homo sapiens |
| CL | 4.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.5 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 4.7 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 4374.09 | nM | Homo sapiens |
| Fu | 0.96 | - | Homo sapiens |
| Fu | 0.96 | - | Homo sapiens |
| Fu | 0.157 | - | Homo sapiens |
| Fu | 0.139 | - | Macaca fascicularis |
| Fu | 0.398 | - | Canis lupus familiaris |
| Fu | 0.167 | - | Cavia porcellus |
| Fu | 0.377 | - | Mus musculus |
| Fu | 0.435 | - | Rattus norvegicus |
| Fu | 0.148 | - | Rattus norvegicus |
| MRT | 6.7 | hr | Homo sapiens |
| T1/2 | 5.4 | hr | Homo sapiens |
| T1/2 | 6.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Streptokinase A | EC50 | = | 64.0 | nM | 7.19 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptococcus sp. 'group A' | EC50 | = | 115.0 | nM | 6.94 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptococcus | EC50 | = | 142.0 | nM | 6.85 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... | - |
| Unchecked | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of Plasmodium falciparum NF54 Gyrase B | 38171145 |
| Plasmodium falciparum | IC50 | = | 20000.0 | nM | 4.7 | Antimalarial activity against blood stage form of Plasmodium falciparum assessed... | 24650715 |
Literature References
Data from ChEMBL 36 via Core Engine