Compound Detail
CHEMBL279085
TALIPEXOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL279085 |
| Name | TALIPEXOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | DHSSDEDRBUKTQY-UHFFFAOYSA-N |
5
Targets
7
Activities
3
Assay Types
0
PK Parameters
20
Publications
2
Known Names
Molecular Properties
209.3
MW (Da)
1.31
ALogP
4
HBA
1
HBD
42.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
Ki 4 meas. best 8.24
IC50 2 meas. best 7.6
EC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 8.24 | 6.905 | 5.8 | 2 |
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 7.6 | 7.6 | 25.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 7.17 | 7.17 | 67.6 | 1 |
| Cavia porcellus CHEMBL369 | EC50 | 7.0 | 7.0 | 100.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.21 | 6.21 | 616.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 5.8 | nM | 8.24 | In vitro binding affinity to rat striatal Dopamine receptor D2 was determined us... | 9435894 |
| Adrenergic receptor alpha-2 | IC50 | = | 25.0 | nM | 7.6 | Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit t... | 6142954 |
| D(3) dopamine receptor | Ki | = | 67.61 | nM | 7.17 | Displacement of [125I]iodosupride from human recombinant dopamine D3 receptor ex... | - |
| Cavia porcellus | EC50 | = | 100.0 | nM | 7.0 | Concentration-related inhibition of response to sympathetic nerve stimulation in... | 6136610 |
| D(2) dopamine receptor | Ki | = | 616.6 | nM | 6.21 | Displacement of [125I]iodosupride from human recombinant dopamine D2S receptor e... | - |
| D(2) dopamine receptor | Ki | = | 2700.0 | nM | 5.57 | In vitro binding affinity to rat striatal Dopamine receptor D2 was determined us... | 9435894 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9435894 | 10.1021/jm9703653 | D(2) dopamine receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Cannabinoid receptor 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-1 adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Nuclear receptor subfamily 1 group I member 2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2B | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 2 |
| 6142954 | 10.1021/jm00370a011 | Oryctolagus cuniculus | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 6264080 | 10.1021/jm00137a006 | Adrenergic receptor alpha | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Progesterone receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Androgen receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| - | 10.1039/C9MD00379G | D(2) dopamine receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| - | 10.1039/C9MD00379G | D(3) dopamine receptor | 1 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-2 adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine