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Compound Detail

CHEMBL283847

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CCCn1c(=O)c2c(nc(/C=C/c3cc(OC)c(OC)cc3OC)n2C)n(CCC)c1=O

Basic Information

ChEMBL ID CHEMBL283847
Phase Preclinical
Structure Type MOL
InChI Key PXDSJJXIKQJRHR-MDZDMXLPSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

442.5
MW (Da)
2.91
ALogP
9
HBA
0
HBD
89.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H30N4O5
MW 442.52
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.66

Activity Summary

Ki 4 meas. best 6.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 6.77 6.77 170.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 6.49 6.49 327.0 1
Adenosine receptor A1
CHEMBL318
Ki 6.16 6.16 689.0 1
Adenosine receptor A1
CHEMBL2304404
Ki 5.48 5.48 3300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)00440-X Adenosine receptor A1 1
- 10.1016/S0960-894X(97)00440-X Adenosine receptor A2a 1
- 10.1016/S0960-894X(97)00440-X Adenosine receptors; A1 & A2a 1
- 10.1016/S0960-894X(97)00440-X Mus musculus 1
8496902 10.1021/jm00062a005 Adenosine receptor A1 1
8496902 10.1021/jm00062a005 Adenosine A2 receptor 1
8496902 10.1021/jm00062a005 Adenosine receptors; A1 & A2 1

Data from ChEMBL 36 via Core Engine