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Compound Detail

CHEMBL289413

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CCCn1c(=O)c2[nH]c(-c3ccccc3)cc2n(CCC)c1=O

Basic Information

ChEMBL ID CHEMBL289413
Phase Preclinical
Structure Type MOL
InChI Key UBJAFKSHHKGNMT-UHFFFAOYSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

311.4
MW (Da)
2.98
ALogP
4
HBA
1
HBD
59.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H21N3O2
MW 311.39
Aromatic Rings 3
Heavy Atoms 23
NP-Likeness -0.92

Activity Summary

Ki 6 meas. best 7.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 7.89 7.89 13.0 1
Adenosine receptor A1
CHEMBL226
Ki 7.47 7.47 34.0 1
Adenosine receptor A3
CHEMBL256
Ki 7.02 7.02 96.0 1
Adenosine receptor A2b
CHEMBL255
Ki 6.64 6.64 229.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 6.35 6.35 450.0 1
Adenosine receptor A2a
CHEMBL251
Ki 6.19 6.19 646.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8182711 10.1021/jm00036a019 Adenosine receptor A1 1
8182711 10.1021/jm00036a019 Adenosine A2 receptor 1
8182711 10.1021/jm00036a019 Adenosine receptors; A1 & A2 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A2b 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A2a 1
18938084 10.1016/j.bmc.2008.09.067 Unchecked 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A1 1
18938084 10.1016/j.bmc.2008.09.067 Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine