Compound Detail
CHEMBL305978
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Basic Information
| ChEMBL ID | CHEMBL305978 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMUROSQCXMKHEN-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
262.3
MW (Da)
4.15
ALogP
4
HBA
0
HBD
52.1
PSA (Ų)
0.54
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.92
IC50 1 meas. best 4.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.92 | 4.92 | 12023.0 | 1 |
| Tyrosine-protein phosphatase non-receptor type 7 CHEMBL2219 | IC50 | 4.91 | 4.91 | 12400.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.67 | 4.67 | 21557.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Zinc finger protein mex-5 | EC50 | = | 12023.0 | nM | 4.92 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Tyrosine-protein phosphatase non-receptor type 7 | IC50 | = | 12400.0 | nM | 4.91 | PUBCHEM_BIOASSAY: MOA HePTP Fluorescent secondary assay for identification of re... | - |
| RNA-binding protein pos-1 | EC50 | = | 21557.0 | nM | 4.67 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8667360 | 10.1021/jm950727b | Platelet-derived growth factor receptor | 1 |
| 21478016 | 10.1016/j.bmcl.2011.03.042 | Unchecked | 1 |
| 21478016 | 10.1016/j.bmcl.2011.03.042 | Nucleic Acid | 1 |
Data from ChEMBL 36 via Core Engine