Compound Detail
CHEMBL3747066
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Basic Information
| ChEMBL ID | CHEMBL3747066 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PATLKHJBXKHOLA-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
591.4
MW (Da)
5.10
ALogP
5
HBA
3
HBD
110.5
PSA (Ų)
0.32
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| A-375 CHEMBL613859 | IC50 | 8.62 | 8.62 | 2.4 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 7.19 | 7.19 | 65.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| A-375 | IC50 | = | 2.4 | nM | 8.62 | Antiproliferative activity against human A375 cells harboring BRAF(V600E) mutati... | 26611920 |
| Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubat... | 26611920 |
| NON-PROTEIN TARGET | IC50 | = | 65.0 | nM | 7.19 | Antiproliferative activity against human HCT116 cells harboring K-Ras G13D mutat... | 26611920 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26611920 | 10.1016/j.bmcl.2015.11.004 | NON-PROTEIN TARGET | 2 |
| 26611920 | 10.1016/j.bmcl.2015.11.004 | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
| 26611920 | 10.1016/j.bmcl.2015.11.004 | A-375 | 1 |
Data from ChEMBL 36 via Core Engine