Compound Detail
CHEMBL4060919
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Basic Information
| ChEMBL ID | CHEMBL4060919 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NTYXFJPDTRPPAO-OAHLLOKOSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
2.35
ALogP
6
HBA
1
HBD
89.9
PSA (Ų)
0.72
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.82
IC50 3 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 8.52 | 8.0733 | 3.0 | 3 |
| HCC827 CHEMBL4296422 | EC50 | 6.82 | 6.82 | 150.0 | 1 |
| NCI-H1975 CHEMBL614348 | EC50 | 6.16 | 6.16 | 690.0 | 1 |
| A-431 CHEMBL614069 | EC50 | 4.7 | 4.7 | 19900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 3.0 | nM | 8.52 | Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculo... | 28853575 |
| Epidermal growth factor receptor | IC50 | = | 10.0 | nM | 8.0 | Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expres... | 28853575 |
| Epidermal growth factor receptor | IC50 | = | 20.0 | nM | 7.7 | Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expre... | 28853575 |
| HCC827 | EC50 | = | 150.0 | nM | 6.82 | Antiproliferative activity against human HCC827 cells harboring EGFR-delE746_A75... | 28853575 |
| NCI-H1975 | EC50 | = | 690.0 | nM | 6.16 | Antiproliferative activity against human NCI-H1975 cells harboring EGFR-L858R/T7... | 28853575 |
| A-431 | EC50 | = | 19900.0 | nM | 4.7 | Antiproliferative activity against human A431 cells expressing wild type EGFR in... | 28853575 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28853575 | 10.1021/acs.jmedchem.7b00515 | Epidermal growth factor receptor | 3 |
| 28853575 | 10.1021/acs.jmedchem.7b00515 | Unchecked | 2 |
| 28853575 | 10.1021/acs.jmedchem.7b00515 | A-431 | 1 |
| 28853575 | 10.1021/acs.jmedchem.7b00515 | HCC827 | 1 |
| 28853575 | 10.1021/acs.jmedchem.7b00515 | NCI-H1975 | 1 |
| 28853575 | 10.1021/acs.jmedchem.7b00515 | A549 | 1 |
Data from ChEMBL 36 via Core Engine