Compound Detail
CHEMBL436783
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C[C@@H](O)[C@H](NC(=O)[C@@H]1CSC[C@@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL436783 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DTIUHIDPXKIHMG-MNTGUQQXSA-N |
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
1000.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 8.31 | 8.31 | 4.9 | 2 |
| Somatostatin receptor type 5 CHEMBL4318 | IC50 | 8.26 | 8.26 | 5.5 | 2 |
| Somatostatin receptor type 2 CHEMBL3207 | IC50 | 7.81 | 7.795 | 15.6 | 2 |
| Rattus norvegicus CHEMBL376 | IC50 | 7.16 | 7.16 | 70.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 5 | IC50 | = | 4.92 | nM | 8.31 | compound was tested for the inhibition of human somatostatin receptor 5 (hSSTR5) | 9216844 |
| Somatostatin receptor type 5 | IC50 | = | 4.92 | nM | 8.31 | Tested for inhibition of radioligand binding to cloned somatostatin receptor hSS... | 9216843 |
| Somatostatin receptor type 5 | IC50 | = | 5.5 | nM | 8.26 | Compound was tested for the inhibition of rSSTR5 | 9216844 |
| Somatostatin receptor type 5 | IC50 | = | 5.5 | nM | 8.26 | Tested for inhibition of radioligand binding to cloned somatostatin receptor rSS... | 9216843 |
| Somatostatin receptor type 2 | IC50 | = | 15.6 | nM | 7.81 | Compound was tested for the inhibition of mSSTR2b | 9216844 |
| Somatostatin receptor type 2 | IC50 | = | 16.6 | nM | 7.78 | Tested for inhibition of radioligand binding to cloned somatostatin receptor mSS... | 9216843 |
| Rattus norvegicus | IC50 | = | 70.0 | nM | 7.16 | Tested for inhibition of growth hormone (GH)release from primary cultures of mal... | 9216843 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9216844 | 10.1021/jm960851a | Somatostatin receptor type 5 | 2 |
| 9216843 | 10.1021/jm960850i | Somatostatin receptor type 5 | 2 |
| 9216844 | 10.1021/jm960851a | Somatostatin receptor type 2 | 1 |
| 9216843 | 10.1021/jm960850i | Somatostatin receptor type 2 | 1 |
| 9216843 | 10.1021/jm960850i | Somatostatin receptor type 3 | 1 |
| 9216843 | 10.1021/jm960850i | Somatostatin receptor type 4 | 1 |
| 9216843 | 10.1021/jm960850i | Rattus norvegicus | 1 |
| 9216843 | 10.1021/jm960850i | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine