Compound Detail
CHEMBL4455513
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Basic Information
| ChEMBL ID | CHEMBL4455513 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WZSQCCTZFYLIKW-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
431.5
MW (Da)
2.93
ALogP
6
HBA
1
HBD
85.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transcription initiation factor TFIID subunit 1 CHEMBL3217390 | IC50 | 8.0 | 6.58 | 10.0 | 2 |
| Chromatin remodeling regulator CECR2 CHEMBL3108639 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
| Bromodomain-containing protein 9 CHEMBL3108640 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 5.44 | 5.4 | 3600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transcription initiation factor TFIID subunit 1 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 1... | 30289257 |
| Chromatin remodeling regulator CECR2 | IC50 | = | 230.0 | nM | 6.64 | Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-... | 30289257 |
| Bromodomain-containing protein 9 | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-F... | 30289257 |
| Bromodomain-containing protein 4 | IC50 | = | 3600.0 | nM | 5.44 | Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 1... | 30289257 |
| Bromodomain-containing protein 4 | IC50 | = | 4400.0 | nM | 5.36 | Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 1... | 30289257 |
| Transcription initiation factor TFIID subunit 1 | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 1... | 30289257 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30289257 | 10.1021/acs.jmedchem.8b01225 | Transcription initiation factor TFIID subunit 1 | 2 |
| 30289257 | 10.1021/acs.jmedchem.8b01225 | Bromodomain-containing protein 4 | 2 |
| 30289257 | 10.1021/acs.jmedchem.8b01225 | Bromodomain-containing protein 9 | 1 |
| 30289257 | 10.1021/acs.jmedchem.8b01225 | Chromatin remodeling regulator CECR2 | 1 |
Data from ChEMBL 36 via Core Engine