Compound Detail
CHEMBL4483014
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Basic Information
| ChEMBL ID | CHEMBL4483014 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QKBGNVCABCTNCY-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
3.31
ALogP
7
HBA
1
HBD
74.0
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA-dependent protein kinase catalytic subunit CHEMBL3142 | IC50 | 8.3 | 7.4 | 5.0 | 2 |
| Dual specificity protein kinase TTK CHEMBL3983 | IC50 | 7.7 | 7.7 | 19.9 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 7.6 | 7.6 | 25.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA-dependent protein kinase catalytic subunit | IC50 | = | 5.012 | nM | 8.3 | Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using... | 31851518 |
| Dual specificity protein kinase TTK | IC50 | = | 19.95 | nM | 7.7 | Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human full-le... | 31851518 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 25.12 | nM | 7.6 | Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tag... | 31851518 |
| DNA-dependent protein kinase catalytic subunit | IC50 | = | 316.23 | nM | 6.5 | Inhibition of DNA-PK in human A549 cells assessed as reduction in irradiation-in... | 31851518 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31851518 | 10.1021/acs.jmedchem.9b01684 | DNA-dependent protein kinase catalytic subunit | 2 |
| 31851518 | 10.1021/acs.jmedchem.9b01684 | No relevant target | 1 |
| 31851518 | 10.1021/acs.jmedchem.9b01684 | Dual specificity protein kinase TTK | 1 |
| 31851518 | 10.1021/acs.jmedchem.9b01684 | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine