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Compound Detail

CHEMBL4752614

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C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@]2(O)c1cn(-c2cccc(O)c2)nn1

Basic Information

ChEMBL ID CHEMBL4752614
Phase Preclinical
Structure Type MOL
InChI Key CNCYPHLGQIATRW-YWBWYGPRSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

431.5
MW (Da)
4.42
ALogP
6
HBA
3
HBD
91.4
PSA (Ų)
0.56
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H29N3O3
MW 431.54
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness 0.75

Activity Summary

EC50 3 meas. best 7.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Estrogen receptor beta
CHEMBL242
EC50 7.92 7.8 12.0 2
Estrogen receptor
CHEMBL206
EC50 7.17 7.17 68.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32912438 10.1016/j.bmc.2020.115670 Estrogen receptor beta 4
32912438 10.1016/j.bmc.2020.115670 Estrogen receptor 3
32912438 10.1016/j.bmc.2020.115670 Unchecked 1

Data from ChEMBL 36 via Core Engine