Compound Detail
CHEMBL5185440
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CN1CCN(C2CCN(c3ccc(Nc4ncc(Cl)c(O[C@@H]5CO[C@H]6[C@@H]5OC[C@H]6O)n4)cc3Cl)CC2)CC1
Basic Information
| ChEMBL ID | CHEMBL5185440 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APDFRGIBBFMHRS-MOUTVQLLSA-N |
6
Targets
7
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
565.5
MW (Da)
2.65
ALogP
10
HBA
2
HBD
95.5
PSA (Ų)
0.54
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
| Non-receptor tyrosine-protein kinase TYK2 CHEMBL3553 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 6.54 | 6.54 | 290.0 | 1 |
| U-937 CHEMBL612794 | IC50 | 6.28 | 6.28 | 527.4 | 1 |
| BaF3 CHEMBL614524 | IC50 | 5.86 | 5.82 | 1381.7 | 2 |
| Tyrosine-protein kinase JAK1 CHEMBL2835 | IC50 | 5.82 | 5.82 | 1517.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infecti... | 35860875 |
| Non-receptor tyrosine-protein kinase TYK2 | IC50 | = | 150.0 | nM | 6.82 | Inhibition of human TYK2 by FRET assay | 35860875 |
| Tyrosine-protein kinase JAK2 | IC50 | = | 290.0 | nM | 6.54 | Inhibition of GST tagged recombinant human JAK2 expressed in baculovirus infecti... | 35860875 |
| U-937 | IC50 | = | 527.4 | nM | 6.28 | Antiproliferative activity against human U-937 cells harboring JAK3 M511135 muta... | 35860875 |
| BaF3 | IC50 | = | 1381.7 | nM | 5.86 | Antiproliferative activity against mouse BaF3 parent cell measured after 72 hrs ... | 35860875 |
| Tyrosine-protein kinase JAK1 | IC50 | = | 1517.0 | nM | 5.82 | Inhibition of GST-tagged recombinant human JAK1 (866 to 1154 residues) expressed... | 35860875 |
| BaF3 | IC50 | = | 1648.3 | nM | 5.78 | Antiproliferative activity against mouse BaF3 cells harboring JAK3 M5111 mutant ... | 35860875 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35860875 | 10.1021/acs.jmedchem.2c00922 | BaF3 | 4 |
| 35860875 | 10.1021/acs.jmedchem.2c00922 | Tyrosine-protein kinase JAK1 | 1 |
| 35860875 | 10.1021/acs.jmedchem.2c00922 | Tyrosine-protein kinase JAK2 | 1 |
| 35860875 | 10.1021/acs.jmedchem.2c00922 | Tyrosine-protein kinase JAK3 | 1 |
| 35860875 | 10.1021/acs.jmedchem.2c00922 | Non-receptor tyrosine-protein kinase TYK2 | 1 |
| 35860875 | 10.1021/acs.jmedchem.2c00922 | U-937 | 1 |
Data from ChEMBL 36 via Core Engine