Compound Detail
CHEMBL5202943
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5202943 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KCWGQPNZUSKGQY-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
404.4
MW (Da)
1.93
ALogP
8
HBA
1
HBD
95.6
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL4066 | IC50 | 7.54 | 7.54 | 29.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.15 | 7.15 | 71.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 1.1 | nM | 8.96 | Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 resi... | 36356320 |
| Fibroblast growth factor receptor 3 | IC50 | = | 29.0 | nM | 7.54 | Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate read... | 36356320 |
| Fibroblast growth factor receptor 1 | IC50 | = | 71.0 | nM | 7.15 | Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as subs... | 36356320 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Fibroblast growth factor receptor 3 | 2 |
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Fibroblast growth factor receptor 1 | 1 |
| 36356320 | 10.1021/acs.jmedchem.2c01366 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine