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Compound Detail

CHEMBL5556048

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NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)COCCN)C(c1ccccc1)c1ccccc1)C(N)=O

Basic Information

ChEMBL ID CHEMBL5556048
Phase Preclinical
Structure Type MOL
InChI Key AWCRDYNBAFPCKL-ZOIIQZBTSA-N
7
Targets
9
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

1540.9
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C82H113N19O11
MW 1540.93

Activity Summary

IC50 9 meas. best 5.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
U-937
CHEMBL612794
IC50 5.03 5.03 9400.0 1
Unchecked
CHEMBL612545
IC50 4.8 4.8 15700.0 1
A20
CHEMBL613850
IC50 4.79 4.79 16400.0 1
HeLa
CHEMBL399
IC50 4.3 4.3 50000.0 1
ES-2
CHEMBL5058622
IC50 4.26 4.26 55200.0 1
NCI/ADR-RES
CHEMBL613829
IC50 4.18 4.18 65800.0 1
MRC5
CHEMBL614181
IC50 4.17 4.17 67400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine