Assay Detail
Functional
CHEMBL5520187
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Cytostatic activity against human U-937 cells after 24 hrs by CCK-8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Three Rounds of Stability-Guided Optimization and Systematical Evaluation of Oncolytic Peptide LTX-315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.84 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555708 | — | — | 1 | 5.28 |
| CHEMBL5555594 | — | — | 1 | 5.17 |
| CHEMBL4297628 | RUXOTEMITIDE | 2.0 | 1 | 5.06 |
| CHEMBL5556048 | — | — | 1 | 5.03 |
| CHEMBL5561453 | — | — | 1 | 4.98 |
| CHEMBL5564867 | — | — | 1 | 4.77 |
| CHEMBL5559375 | — | — | 1 | 4.75 |
| CHEMBL5561051 | — | — | 1 | 4.59 |
| CHEMBL5549764 | — | — | 1 | 4.49 |
| CHEMBL5566008 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555708 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5555594 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4297628 | RUXOTEMITIDE | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5556048 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5561453 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL5564867 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5559375 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL5561051 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL5549764 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL5566008 | — | IC50 | = | 56100.0 | nM | 4.25 |